A lab focused on DNA double-strand break repair and human diseases

1.Masson, J.-Y.,Li, T., Boucher, I., and Brzezinski, R. (1993). Factors governing efficient chitosanase production by recombinant Streptomyces lividansstrains carrying the cloned chs gene from StreptomycesN174. In: Chitin Enzymology. Ed. R.A.A. Muzzarelli. European Chitin Society, Ancona. pp 423-430.

 

2.Masson, J.-Y.,Denis, F., and Brzezinski, R. (1994). Primary sequence of the chitosanase from Streptomycessp. strain N174 and comparison with other endoglycosidases. Gene 140, 103-7.

 

3.Audet, J. F., Masson, J.-Y.,Rosen, G. D., Salesse, C., and Guerin, S. L. (1994). Multiple regulatory elements control the basal promoter activity of the human a4 integrin gene. DNA & Cell Biology 13, 1071-85.

 

4.Masson, J.-Y.,Boucher, I., Guérin, S.L., Brzezinski, R. (1995). Effect of regulatory sequence substitution on chitosanase production from a cloned gene in Streptomyces lividans. In: Chitin World. Ed. Z. Karnicki, M.M. Brzezki, J. Dutkiewicz & A. Wojtasz-Pajak, Editors, Elsevier Applied Science, Amsterdam. pp 311-320.

 

5.Masson, J.-Y., Boucher, I., Neugebauer, W. A., Ramotar, D., and Brzezinski, R. (1995). A new chitosanase gene from a Nocardioidessp. is a third member of glycosyl hydrolase family 46. Microbiology 141, 2629-35.

 

6. He, C. H., Masson, J.-Y.,and Ramotar, D. (1996). Functional mitochondria are essential for Saccharomyces cerevisiaecellular resistance to bleomycin. Current Genetics 30, 279-83.

 

7. He, C. H., Masson, J.-Y.,and Ramotar, D. (1996). A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene. Canadian Journal of Microbiology 42, 1263-6.

 

8.Masson, J.-Y.,Tremblay, S., and Ramotar, D. (1996). TheCaenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coliand yeast apurinic/apyrimidinic endonuclease. Gene179, 291-3.

 

9.Masson, J.-Y.,Vadnais, J., and Ramotar, D. (1996). The Schizosaccharomyces pombe spqM gene is a new member of the Qm transcription factor family. Gene170, 153-4.

 

10. Ramotar, D., and Masson, J.-Y. (1996).Saccharomyces cerevisiae DNA repair processes: an update. Molecular & Cellular Biochemistry 158, 65-75.

 

11. Ramotar, D., and Masson, J.-Y. (1996). A Saccharomyces cerevisiaemutant defines a new locus essential for resistance to the antitumour drug bleomycin. Canadian Journal of Microbiology 42, 835-43.

 

12.Masson, J.-Y.,and Ramotar, D. (1996). The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants. Molecular & Cellular Biology16, 2091-100.

 

13.Masson, J.-Y., and Ramotar, D. (1997). Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III. Molecular Microbiology 24, 711-21.

 

14. Ramotar, D., Vadnais, J., Masson, J.-Y.,and Tremblay, S. (1998). Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coliendonuclease IV family of DNA repair proteins. Biochim Biophys Acta 1396: 15-20.

 

15.Masson, J.-Y.,and Ramotar, D. (1998). The transcriptional activator Imp2p maintains ion homeostasis inSaccharomyces cerevisiae. Genetics 149, 893-901.

 

16. Ramotar, D., Belanger, E., Brodeur, I., Masson, J.-Y., and Drobetsky, E. A. (1998). A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide. Journal of Biological Chemistry 273, 21489-96.

 

17. Yang, X., Tellier, P., Masson, J.-Y.,Vu, T., and Ramotar, D. (1999). Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV. Biochemistry 38, 3615-23. 

 

18. Passy, S.I., Yu, X., Li, Z., Radding, C.M., Masson, J.-Y.,West, S.C., and Egelman, E.H. (1999). Human Dmc1 protein binds DNA as an octameric ring. Proceedings of the National Academy of Sciences of the USA 96, 10684-10688.

 

19.Masson, J.-Y.,Davies, A. A., Hajibagheri, N., Van Dyck, E., Benson, F. E., Stasiak, A.Z., Stasiak, A., and West, S. C. (1999). The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51. EMBO Journal 18, 6552-60.

 

20. McIlwraith, M.J., Van Dyck, E., Masson, J.-Y.,Stasiak, A.Z., Stasiak, A., and West, S. C. (2000). Reconstitution of the strand invasion step of double-strand break repair using human rad51 rad52 and RPA proteins. Journal of Molecular Biology 304, 151-64.

 

21.Masson, J.-Y., and West, S. C. (2001).The Rad51 and Dmc1 recombinases: a non-identical twin relationship. Trends in Biochemical Sciences 26, 131-136.

 

22. West, S.C., Chappell, C., Hanakahi, L.A., Masson, J.-Y.,McIlwraith, M.J., Van Dyck, E. (2000). Double-strand break repair in human cells. Cold Spring Harbor Quant. Biol. 65,613 pages.

 

23. Davies, A. A., Masson, J.-Y.,McIlwraith, M.J., Stasiak, A.Z., Stasiak, A., Ventikaraman, A.R., and West, S. C. (2001). Role of BRCA2 in control of the  RAD51 recombination and DNA repair protein. Molecular Cell 7, 273-282. 

 

24.Masson, J.-Y.,Stasiak, A.Z., Stasiak, A., Benson, F. E., and West, S. C. (2001). Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Proceedings of the National Academy of Sciences of the USA 98, 8440-8446. 

 

25. Masson, J.-Y.,Tarsounas, M.C., Stasiak, A.Z., Stasiak, A., Shah, R., McIlwraith, M.J., Benson, F. E., and West, S. C. (2001). Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes and Development, 15: 3296-3307. 

 

26. French, C.A., Masson, J.-Y.,Griffin, C.S., O’Regan, P., West, S. C., and Thacker, J. (2002). Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. Journal of Biological Chemistry, 277: 19322-19330.

 

27. Henry-Moyatt, J., Jackson, D., Masson, J.-Y.,Johnson, P.A., Clements, P.A., Benson, F.E., Thompson, L.H., Takeda, S., West, S. C., and Caldecott, K.W. (2003). XRCC3 and RAD51 modulate replication fork progression on damaged chromosomes. Molecular Cell, 11: 1109-1117. 

 

28. Liu, Y., Masson, J.-Y.,Shah, R., O’Regan, P., and West, S. C. (2004). RAD51C is required for Holliday junction processing in mammalian cells. Science, 303: 243-246. 

 

29. Allard, S., Masson, J.-Y., and Côté, J.(2004). Chromatin remodeling and the maintenance of genome integrity. Biochimica et Biophysica Acta, 1677: 158-64.

 

30. Liu, Y., Stasiak,  AZ., Masson, J.-Y., McIlwraith, MJ., Stasiak. A., West SC. and West, S. C. (2004). Conformational Changes Modulate the Activity of Human RAD51 Protein. Journal of  Molecular Biology,  337: 817-27.

 

31. Hussain S., Wilson J.B., Medhurst A.L., Hejna J., Witt E., Ananth S., Davies A., Masson J.-Y.,Moses R., West S.C., de Winter J.P., Ashworth A., Jones N.J., and Mathew C.G. (2004). Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum. Mol. Genet, 13:1241-8.

            

32. Sauvageau, S., Ploquin M., and Masson, J.-Y. (2004). Exploring the multiple facets of the meiotic recombinase Dmc1. Bioessays 26:1151-1155.

 

33. Boisvert, F.-M., Déry, U., Masson, J.-Y.,and Richard, S. (2005). Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes and Development,19: 671-6. 

 

34. Boisvert, F.-M., Hendzel, M.J., Masson, J.-Y.,and Richard, S. (2005). Methylation of MRE11 regulates its nuclear compartmentalization. Cell Cycle, 4: 981-9. 

 

35. Boisvert, F.-M., Déry, U., Masson, J.-Y.,Richard, S. (2005). [A new role for arginine methylation in DNA repair]. Medecine Sciences (Paris). 21, 579-81.

 

36.  Petukhova, G., Pezza, R., Vanevski, F., Ploquin, M., Masson, J.-Y.,  and Camerini-Otero, R.D. (2005). The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. Nature Structural & Molecular Biology, 12: 449-53. 

 

37. Sauvageau, S., Stasiak, A.Z., Banville, I., Ploquin M., Stasiak, A., and Masson, J.-Y.(2005). Fission yeast rad51 and dmc1: two efficient DNA recombinases forming helical nucleoprotein filaments. Molecular and Cellular Biology, 25: 4377-87.

 

38.Haince, J.-F., Rouleau, M., Hendzel, M.J., Masson, J.-Y.,Poirier, GG. (2005). Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy. Trends in Molecular Medecine, 11:456-63.

 

39. Robert, F., Hardy, S., Nagy, Z., Baldeyron, C., Murr, R., Dery, U., Masson, J.-Y.,Papadopoulo, D., Herceg, Z., Tora, L. (2006). The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Molecular and Cellular Biology, 26: 402-12.

 

40. Rodrigue, A., Lafrance, M., Gauthier, M.-C., McDonald, D., Hendzel, M., Jasin, M., West, S.C., and Masson, J.-Y.(2006) Interplay between human DNA repair proteins at a unique double-strand breaks in vivo. EMBO Journal 25:222-31.

 

41. Déry, U., and Masson, J.-Y. (2007). Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications. DNA repair, 6: 561-577. 

 

42. Ploquin M., Petukhova, G.V., Morneau, D., Déry, U., Bransi, A., , Stasiak, A., Camerini-Otero, R.D., and Masson, J.-Y.(2007). Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases. Nucleic Acids Research, 35: 2719-33.

 

43. Haince, J.-F., McDonald, D., Rodrigue, A., Déry, U., Masson, J.-Y., Hendzel, M.J., and Poirier GG. (2008) PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. Journal of Biological Chemistry 283:1197-208.

 

44. Déry, U., Coulombe, Y., Rodrigue, A., Stasiak, A., Richard, S., and Masson, J.-Y. (2008).A glycine-arginine domain in control of the human MRE11 DNA repair protein. Molecular and Cellular Biology 28:3058-69. A picture of this article is on the cover of the issue. 

 

45. Ploquin, M., Bransi, A., Paquet, E., Stasiak, A., Stasiak, A., Yu, X., Cieslinska, A.M., Egelman, E.H., Moineau, S.,  and Masson, J.-Y.(2008). Functional and structural basis for a bacteriophage homologue of human RAD52. Current Biology 18:1142-6.

 

46. Lee, S., Roques, C., Masson, J.-Y.,Baker, M.D. (2009). Brca2 deficiency in homologous recombination and its recovery by wild-type RAD51 expression. DNA repair 8: 170-81. 

 

47. Turanga, R.V.N., Paquet, E.R., Sild, M., Vignard, J., Garand, C., Johnson, F.B., Masson J.-Y.,Lebel, M. (2009). The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell cycle 8: 2080-92.  

 

48. Roques, C., Coulombe, Y., Delannoy, M., Vignard, J., Grossi, S., Brodeur, I., Rodrigue, A., Gautier, J., Stasiak, A., Stasiak, A., Constantinou, A., and Masson J.-Y. (2009). MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO journal  28:2400-13.

 

49. Scaltriti, E., Tegoni, M., Rivetti,C., Launay, H., Masson, J.-Y., Tremblay, D., Magadan, A., Moineau, S., Ramoni, R., Lichière, J., Campanacci, V., Cambillau, C.,  and Ortiz-Lombardía, M. (2009) Crystal Structure and Characterization of a New Type of Single Stranded DNA Binding Protein from the Lactococcal phage p2. Molecular Microbiology 73: 1156-1170. 

 

50. Roques, C., and Masson, J.-Y. (2010). FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1. Cell cycle 9: 209-210. 

 

51. Scaltriti, E., Moineau, S., Launay, H., Masson, J.-Y.,  Rivetti, C., Ramoni, R., Campanacci, V., Tegoni, M., and Cambillau, C. (2010). Deciphering the function of lactococcal phage ul36 Sak domains. J Struct Biol. 170:462-9.

 

52. Buisson, R., Dion-Côté, A., Coulombe, Y., Launay, H., Cai, H., Stasiak, A., Stasiak, A., Xia, B., and Masson, J.-Y. (2010). Cooperation of breast cancer proteins PALB2 and piccoloBRCA2 in stimulating homologous recombination. Nature Structural and Molecular Biology 17:1247-54. 

 

53. Rouleau, M., Sanexa, V., Rodrigue, A., Paquet, E.R., Gagnon, A., Hendzel, M.J.,Masson, J.-Y.,Ekker, M., Poirier, G.G. (2010). A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development. PloS ONE 6(1):e15834. 

 

54. Martinez-Marignac, V.L., Rodrigue, A., Davidson, D., Couillard, M., Al-Moustafa, A.-E.,  Abramovitz, M., Foulkes, W.D., Masson, J.-Y.,and Aloyz, R. (2011). The effect of a DNA repair gene on cellular invasiveness: Xrcc3 over expression in breast cancer cells. PloS ONE 6(1):e16394.

 

55. Lachapelle, S., Gagné, J.-P., Garand C., Desbiens, M., Coulombe, Y., Bohr, V.A., Hendzel, M.J., Masson, J.-Y., Poirier, G.G., and Lebel, M. (2011). Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. Journal of Proteome Research 10:1216-27. 

 

56. Scaltriti, E., Launay, H., Genois, M.-M., Bron, P., Rivetti,C., Grolli, S., Ploquin, M., Campanacci, V., Tegoni, M., Cambillau, C., Moineau, S., and Masson, J.-Y.(2011). Lactococcal Phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism. Molecular Microbiology 80: 102-116. 

 

57. Vignard, J., Charbonnel, C., and Masson J.-Y. (2011). Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA. Cell Cycle 10: 1025-30. 

 

58. Yu, Z., Vogel, G., Coulombe, Y., Dubeau, D., Spehalski, E., Hébert, J., Ferguson, D.O., Masson, J.-Y., and Richard, S. (2011).  The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Research 22: 305-320. 

59. Davidson, D., Coulombe, Y., Martinez-Marignac, V.L., Amrein, L., Grenier J., Hodkinson, K., Masson, J.-Y., Aloyz, R., Panasci, L.(2011). Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells.Invest New Drugs.30 : 1248-1256.

60. Bleuyard, J.-Y., Buisson, R., Masson, J.-Y.,Esashi, F. (2011). ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. EMBO reports 13: 135-141. 

61. Bukhari, S.I, Vasquez-Rifo, A., Gagné, D., Paquet, E., Zetka, M., Robert, C., Masson, J.-Y.*, Simard, M*.(2012).The microRNA pathway controls germ cells proliferation and differentiation in C. elegans. Cell Research. 22: 1034-1045. * Co-corresponding authors. 

 

62. Ismail, I.H., Gagné, J.-P., Caron, M.-C., McDonald, D., Xu, Z., Masson J.-Y. Poirier, G.G., and Hendzel, M. (2012). CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage.Nucleic Acids Research, 40: 5497-510. 

 

63. Genois, M.-M., Mukherjee, A., Ubeda, J.-M., Buisson, R., Paquet, E., Roy, G., Plourde, M., Coulombe, Y., Ouellette, M., and Masson J.-Y. (2012). Leishmania infantum Brca2 and Rad51 promote homologous recombination and genome stability.Nucleic Acids Research 40: 6570-84. 

 

64. Andrin, C., McDonald, D., Atwood, K., Rodrigue, A., Ghosh, S., Mirzayans, R., Masson J.-Y., Dellaire, G., and Hendzel M.J. (2012). A Requirement for polymerized actin in DNA double strand break repair. Nucleus 3:384-95. 

 

65. Turcotte, V., Fortin, S., Vevey, F., Coulombe, Y., Lacroix, J., Côté, M.-F., Masson J.-Y., and C-Gaudreault, R. (2012). Synthesis, Biological Evaluation, and Structure-Activity Relationships of Novel Substituted N-Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle Progression in S-Phase and Inducing DNA Double-Strand Breaks.J. Med. Chem.  55 : 6194-508.

 

66. Krietsch, J., Caron, M.-C., Gagné, J.P., Ethier, C., Vignard, J., Vincent, M., Rouleau, M., Poirier, G.G.,  and Masson J.-Y. (2012).PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Research 40:10287-301.

 

67.Buisson, R. and Masson J.-Y. (2012). PALB2 self-interaction controls homologous recombination. Nucleic Acids Research 40: 10312-23.

 

68. Rodrigue, A., Coulombe, Y., Jacquet, K., Gagné, J.P., Roques, C., Poirier, G. and Masson J.-Y. (2013).  The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.Journal of Cell Science 126: 348-59. 

 

69. Torresilla, C., Larocque, E., Landry, S.,  Halin, M.,  Coulombe, Y., Masson, J.-Y.,  Mesnard, J.-M., and Barbeau B., (2013).  Detection of the HIV-1 minus strand-encoded Antisense Protein and its association with autophagy, J. Virology 87: 5089-105.

 

70. Buisson, R. and Masson, J.-Y.(2013).  Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair. [Article in French]. Medecine Sciences, 29: 301-7

 

71. Suhasini, A.N., Sommers, J.A., Muniandy, P.A., Coulombe, Y., Cantor, S.B., Masson, J.-Y., Seidman, M.-M., Brosh, R.M. (2013).  Fanconi Anemia Group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Molecular and Cellular Biology 33: 2212-27. 

 

72. Krietsch,  J., Rouleau, M., Pic, E., Ethier, C., Dawson, T.M., Dawson, V.L., Masson, J.-Y., Poirier, G.G., Gagné, J.-P. (2013). Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med. 34, 1066-1087. 

 

73. Feng, Y., Maity, R., Whitelegge, J.P., Hadjikyriacou, A., Zurita-Lopez, C., Al-Hadid, Q., Bedford, M.T., Masson, J.-Y.,and Clarke, S.G. (2013). Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets Histone H2B at R-X-R sites in the N-terminal Basic Region. JBC 288: 37010-25. 

 

74. Maity, R., Pauty, J., Krietsch, J., Buisson, R., Genois, M.-M. Masson, J.-Y. (2013)GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins. J Vis Exp. 80:e50320. 

 

75. Buisson, R., Joshi, N., Pauty, J., Zhao, W.,Maity, R., Coulombe, Y., Sung, P., and Masson, J.-Y.(2014).  Breast cancer proteins PALB2 and BRCA2 stimulate polymerase hfor recombination-associated DNA synthesis at blocked replication forks. Cell Reports 6, 553-564. 

 

76. Genois, M.-M., Paquet, E., Laffitte, M.-C. N., Maity, R., Rodrigue A., Ouellette, M., and Masson, J.-Y.(2014).  DNA repair pathways in trypanosomatids: from DNA repair to drug resistance.Microbiology and Molecular Biology Reviews 78, 40-73. 

 

77. Pauty, J., Rodrigue, A., Couturier, A., Buisson, R. and Masson, J.-Y.(2014) Exploring the roles of PALB2 at the crossroads of DNA repair and cancer. Biochemical Journal 460, 331-342

 

78. Yu, H., Pak, H., Hammond-Martel, I., Ghram, M., Rodrigue, A., Daou, S., Hébert, J., Drobetsky, E., Masson, J.-Y.,  Di Noia, J.M., Bachir Affar, E. (2014). The Tumor Suppressor and Deubiquitinase BAP1 Promotes DNA Double-Strand Breaks Repair. PNAS 111, 285-290. 

 

79.Shibata, A., Moiani, D., Arvai, A.S., Perry, J.J.P., Harding, SM., Genois, M.-M., Maity, R., Kertokalio, A., Romoli, F., Petricci, E., Neale, M.J., Bristow, R.G., Masson, J.-Y., Wyman, C., Jeggo, P., and John A. Tainer. (2014).  DNA double strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Molecular Cell 53, 7-18. 

 

80. Laffitte, M.-C., Genois M.-M., Mukherjee, A., Légaré, D., Masson, J.-Y., andOuellette, M. (2014). Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. Plos Genetics, 10:e1004805. 

 

81. Genois, M.M., Plourde, M., Éthier, C., Roy, G., Poirier, G., Ouellette, M. and Masson, J.-Y.(2015). Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum. Nucleic Acids Research 43, 2701-15. 

 

82. Grote, D., Moison, C., Duhamel, S., Chagraoui, J., Girard, S., Yang, J., Mayotte, N., Coulombe, Y., Masson, J.-Y., Brown, G., Meloche, S., andSauvageau, G. (2015). E4F1 is a master regulator of CHK1 mediated functions. Cell reports 11, 210-9. 

 

83. Gagné-Boulet, M., Moussa, H., Lacroix, J., Côté, M.-F., Masson, J.-Y., Fortin, S. (2015). Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.Eur. J. Med. Chem. 103: 563-73. 

 

84. Loie, E., Charrier, L.E., Sollier, K., Masson, J.-Y., Laprise, P. (2015). CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.Molecular and  Cellular Biology. 35: 3423-35. 

 

85. Gurunathan, G., Yu, Z., Coulombe, Y., Masson, J.-Y., Richard, S.(2015).Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.Sci Rep. 5: 10475. 

 

86. Ismail, I.H., Gagné, J.-P., Genois, M.-M., Strickfaden, H., McDonald, D., Xu, Z., Poirier, G.G., Masson, J.-Y.,Hendzel, M.J. (2015). RNF138 is an E3 ubiquitin ligase that displaces Ku to promote DNA end resection and regulate DNA repair pathway choice. Nature Cell Biology 17, 1446-57. 

 

87. Velic, D., Couturier, A.M., Ferreira, M.T., Rodrigue, A., Poirier, G.G., Fleury, F., and Masson, J.-Y.(2015). DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer. Biomolecules 20, 3204-3259. 

 

88. Pauty, J., Côté, M.-F., Rodrigue, A., Velic, D., Masson, J.-Y., Fortin, S. (2016).  Investigation of the DNA damage response to SFOM-0046, a new small-moleculedrug inducing DNA double-strand breaks. Scientific reports, 6, Article number: 23302 

89. Tkac, J., Xu, G., Adhikary, H., Young, J.T., Gallo, D., Escribado-Diaz, C., Krietsch, J., Orthwein, A., Munro, M., Sol, W., Al-Hakim, A., Lin, Z.-Y., Jonkers, J., Borst, P., Brown, G.W., Gingras, A.-C., Rottengerg, S., Masson, J.-Y., Durocher, D. (2016). HELB inhibits DNA end resection via a negative feedback mechanism.  Molecular Cell 61 :405-18

 

90. Renault, A.-L., Lesueur, F., Coulombe, Y., Gobeil, S., Soucy, P., Hamdi, Y., Desjardins, S., Le Calvez-Kelm, F., Vallée, M., Voegele, C.; Breast Cancer Family Registry, Hopper, J.L., Andrulis, I.L., Southey, M.C., John, E.M., Masson J.-Y., Tavtigian, S.V., Simard, J. (2016). ABRAXAS (FAM175A) and breast cancer susceptibility: no evidence of association in the breast cancer famility registry. PLoS One. 11(6):e0156820. 

 

91. Kaur, S., Coulombe, Y., Ramdzan, Z.M., Leduy, L., Masson, J.-Y., Nepveu, A. (2016). SATB1 functions as an accessory factor in base excision repair. Journal of Biological Chemistry 291(43):22769-22780.  

 

92. Laffitte, M.-C., Leprohon, P., Hainse, M., Légaré, D.,  Masson, J.-Y., and Ouellette, M.(2016). Chromosomal translocations in the parasite Leishmania by a MRE11/RAD50-independent microhomology-mediated end joining mechanism. Plos Genetics 12(6):e1006117.

 

93. Dubois, É.L., Béliveau M., and Masson, J.-Y.(2016). Fanconi anemia animal models - How differences can teach us as much as similarities. Médecine Sciences 32(6): 598-605. 

 

94. Couturier, A.M., Fleury, H., Patenaude, A.-M., Bentley, V., Rodrigue, A., Coulombe, Y., Niraj, J., Pauty, J., Berman, J.N., Dellaire, G., Di Noia, J., Mes-Masson, A.-M., and Masson, J.-Y. (2016). Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.Nucleic Acids Research 44(22): 10879-10897. 

 

95. Fleury, H., Carmona, E., Morin, V.G., Meunier, L., Masson, J.-Y., Tonin, P.N., Provencher, D., Mes-Masson, A.-M. (2016). Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines. Oncotarget 8(25):40152-40168. 

 

96. Buisson, R., Niraj, J.,Rodrigue, A., Ho, C.K., Kreuzer, J., Foo, T.K., Hardy, E.J.L., Dellaire, G., Haas, W., Xia, B., Masson, J.-Y.*and Zou, L.* (2017). Coupling of Homologous Recombination and the Checkpoint by ATR. Molecular Cell 65(2): 336-346. 

* Co-corresponding authors

 

97. Pauty, J., Couturier, A.M., Rodrigue, A., Caron, M.-C., Coulombe, Y., Dellaire, G., andMasson, J.-Y.(2017). Cancer-causing mutations in the tumour suppressor PALB2 reveal a novel cancer mechanism using hidden nuclear export signal in the WD40 repeat motif.Nucleic Acids Research 45(5):2644-2657. 

 

98. Luijsterburg, M.S., Typas, D.,  Caron, M.-C., Wiegant, W.W., van den Heuvel, D., Boonen, R.A .,  Couturier, A.M., Mullenders, L.H, Masson, J.-Y., van Attikum, H. (2017). A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. eLIFE, 6:e20922. 

 

99. Thandapani P, Couturier AM, Yu Z, Li X, Couture JF, Li S, Masson JY*, Richard S*. (2017). Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress. Oncotarget 8: 64918-64931. * Co-corresponding authors

 

100. Joshi, N., Caron, M.-C., Drapeau, K., Bérubé, S., Guitton-Sert, L., Coulombe, Y., Couturier, A.M., Masson, J.-Y.(2017). The identification of FANCD2 DNA binding domains reveals hidden nuclear localization sequences. Nucleic Acids Research 45:8341-8357.

 

101. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. (2017). Chang, E.Y., Novoa, C.A., Aristizabal, M.J., Coulombe, Y., Segovia, R., Chaturvedi, R., Shen, Y., Keong, C., Tam, A.S., Jones, S.J.M., Masson, J.-Y., Kobor, M.S., Stirling, P.C. Journal of Cell Biology 216(12)3991-4005. 

 

102. Salsman, J., Masson, J.-Y., Orthwein, A., Dellaire, G. (2017). CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo. Current Gene Therapy 17(4):263-274. 

 

103. Moiani, D., Ronato, D.A., Brosey, C.A., Arvai, A.S., Syed, A., Masson, J.-Y., Petricci, E., Tainer, J.A. (2018). Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Methods Enzymol. 601:205-241. 

 

104. Carvajal-Maldonado, D., Byrum, A.K., Jackson, J., Wessel, S., Lemaçon, D., Guitton-Sert, L., Quinet, A., Tirman, S., Graziano, S., Masson, J.-Y., Cortez, D., Gonzalo, S., Mosammaparast, N., Vindigni, A. (2018). Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing. Nucleic Acids Research (in press) 

 

105. Bélanger F, Fortier E, Dubé M, Lemay JF, Buisson R, Masson JY, Elsherbiny A, Costantino S, Carmona E, Mes-Masson AM, Wurtele H, Drobetsky E.(2018) Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells.Cancer Res. 78:5561-5573. 

 

106. Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H, Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Côté JF, Masson JY, Maréchal A, Orthwein A. (2018). SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.  EMBO J. 37(18). pii: e100158.

 

107. Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté J.(2018). Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. Proc Natl Acad Sci U S A. 115:10028-10033. 

 

108. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. (2018). Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Nature Communications.  9: 4385

 

109. Castroviejo-Bermejo M, Cruz C, Llop-Guevara A, Gutiérrez-Enríquez S, Ducy M, Ibrahim YH, Gris-Oliver A, Pellegrino B, Bruna A, Guzmán M, Rodríguez O, Grueso J, Bonache S, Moles-Fernández A, Villacampa G, Viaplana C, Gómez P, Vidal M, Peg V, Serres-Créixams X, Dellaire G, Simard J, Nuciforo P, Rubio IT, Dientsmann R, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Déas O, Jonkers J, Masson JY, Cairo S, Judde JG, O'Connor MJ, Díez O, Balmaña J, Serra V. (2018). A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation. EMBO Mol Med. 10(12). pii: e9172

 

110. He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D. (2018) DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells. Nature 563: 522-526. 

 

111. Ducy M, Sesma-Sanz L, Guitton-Sert L, Lashgari A, Gao Y, Brahiti N, Rodrigue A, Margaillan G, Caron MC, Côté J, Simard J, Masson JY. (2019). The Tumor Suppressor PALB2: Inside Out. Trends Biochem Sciences. 44: 226-240.

 

112. Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Côté J. (2019). PRMT7 Methylates Eukaryotic Translation Initiation Factor 2α and Regulates its Role in Stress Granule Formation. Mol Biol Cell. 30 :778-794. 

 

113. Subramania S, Gagné LM, Campagne S, Fort V, O'Sullivan J, Mocaer K, Feldmüller M, Masson JY, Allain FHT, Hussein SM, Huot MÉ. (2019). SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Nucleic Acids Res. 47(8):4181-4197. 

 

114. Herbert K, Binet R, Lambert JP, Louphrasitthiphol P, Kalkavan H, Sesma-Sanz L, Robles-Espinoza CD, Sarkar S, Suer E, Andrews S, Chauhan J, Roberts ND, Middleton MR, Gingras AC, Masson JY, Larue L, Falletta P, Goding CR. (2019). BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma. Genes and Development 33: 310-332. 

 

115. Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit Sharma, Michael Hendzel*, Jean-Yves Masson*, and Guy G. Poirier*. (2019). Emerging roles of eraser enzymes in dynamic control of protein ADP-ribosylation. Nature Communications 10: 1182

*Co-corresponding authors

 

116. Jaigeeth Deveryshetty, Thibaut Peterlini, Mikhail Ryzhikov, Nadine Brahiti, Graham Dellaire, Jean-Yves Massonand Sergey Korolev. Novel RNA and DNA strand exchange activity of the human PALB2 DNA Binding Domain and its critical role for DNA repair in cells. eLife 8: e44063.

 

117. Dubois EL, Guitton-Sert L, Béliveau M, Parmar K, Chagraoui J, Vignard J, Pauty J, Caron MC, Coulombe Y, Buisson R, Jacquet K, Gamblin C, Gao Y, Laprise P, Lebel M, Sauvageau G, D d'Andrea A, Masson JY. (2019). A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2. Nucleic Acids Research47: 7532-7547.  

 

118. Mersaoui SY, Yu Z, Coulombe Y, Karam M, Busatto FF, Masson JY*, Richard S*. (2019). Arginine methylation of DDX5 RGG/RG motif by PRMT5 regulates RNA:DNA resolution. EMBO Journal 38(15):e100986.

* Co-corresponding authors 

 

119. Caron, M.-C., Sharma, A., Myler, L.R., O’Sullivan, J., Tedim Ferreira, M., Rodrigue, A., Coulombe, Y., Ethier, C., Gagné, J.-P., Langelier, M.-F., Pascal, J.M., Finkelstein, I.J.,  Hendzel, M.*, Poirier, G.G.*,  and Masson, J.-Y*. (2019). Poly (ADP-ribose) polymerase 1 antagonizes DNA resection at double-strand breaks. Nature Communications 10: 2954

* Co-corresponding authors 

 

120. Batenburg NL, Walker JR, Coulombe Y, Sherker A, Masson JY, Zhu XD. (2019). CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection. Nucleic Acids Research 47:10678-10692.

 

121. Chang EY, Tsai S, Aristizabal MJ, Wells JP, Coulombe Y, Busatto FF, Chan YA, Kumar A, Dan Zhu Y, Wang AY, Fournier LA, Hieter P, Kobor MS, Masson JY, Stirling PC. (2019). MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nature Communications 10 : 4265. 

 

122. Velic D, Charlier C, Popova M, Jaunet-Lahary T, Bouchouireb Z, Henry S, Weigel P, Masson JY, Laurent A, Nabiev I, Fleury F. (2019). Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches. Biochimie 167:187-197. 

 

123. Rodrigue A, Margaillan G, Torres Gomes T, Coulombe Y, Montalban G, da Costa E Silva Carvalho S, Milano L, Ducy M, De-Gregoriis G, Dellaire G, Araújo da Silva W Jr, Monteiro AN, Carvalho MA, Simard J, Masson JY. (2019).A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor.Nucleic Acids Research 47:10662-10677. 

 

124. Wiltshire T, Ducy M, Foo TK, Hu C, Lee KY, Belur Nagaraj A, Rodrigue A, Gomes TT, Simard J, Monteiro ANA, Xia B, Carvalho MA, Masson JY, Couch FJ. (2019). Functional characterization of 84 PALB2 variants of uncertain significance. Genetics in  Medecine.  22:622-632

 

125.  Rick Boonen, Amélie Rodrigue, Chantal Stoepker, Nandi Celosse, Bas Vroling, Maaike Vreeswijk, Jacques Simard, Fergus Couch, Peter Devilee, Jean-Yves Masson and Haico van Attikum. (2019).  Functional Analysis of PALB2 Genetic Variants that Associate with Breast Cancer. Nature communications, 10:5296. 

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