2017 Molecular cell paper

January 12, 2017

This is wonderful team work with the Zou lab in Harvard and Dellaire lab in Dalhousie. 


Congs to Rémi (former PhD student), Niraj, Amélie & all !!!


Here are the highlights of the paper: 

  • ATR acts after DNA end resection to promote HR

  • The CDK-to-ATR switch after resection is important for efficient HR

  • ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs

  • ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64


See: http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30845-0





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Centre de Recherche du CHU de Québec (Axe Cancer) 

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