This is wonderful team work with the Zou lab in Harvard and Dellaire lab in Dalhousie.
Congs to Rémi (former PhD student), Niraj, Amélie & all !!!
Here are the highlights of the paper:
ATR acts after DNA end resection to promote HR
The CDK-to-ATR switch after resection is important for efficient HR
ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs
ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64