2017 Molecular cell paper

This is wonderful team work with the Zou lab in Harvard and Dellaire lab in Dalhousie.

Congs to Rémi (former PhD student), Niraj, Amélie & all !!!

Here are the highlights of the paper:

  • ATR acts after DNA end resection to promote HR

  • The CDK-to-ATR switch after resection is important for efficient HR

  • ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs

  • ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64

See: http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30845-0

Featured Posts
Recent Posts
Archive
Search By Tags
Follow on Twitter

Centre de Recherche du CHU de Québec (Axe Cancer) 

Centre de Recherche en Cancérologie de l'Université Laval

9, McMahon, Québec (Québec), Canada  G1R 2J6

Tel 418 525-4444 ext. 15154  |  Fax 418 691-5439

© 2014 Genome Stability and DNA double-strand break repair laboratory

Design: Véronique L’Italien