2017 Molecular cell paper

This is wonderful team work with the Zou lab in Harvard and Dellaire lab in Dalhousie.

Congs to Rémi (former PhD student), Niraj, Amélie & all !!!

Here are the highlights of the paper:

  • ATR acts after DNA end resection to promote HR

  • The CDK-to-ATR switch after resection is important for efficient HR

  • ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs

  • ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64

See: http://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30845-0

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Centre de Recherche du CHU de Québec (Axe Cancer) 

Centre de Recherche en Cancérologie de l'Université Laval

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